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“She showed up at the audition with that character fully formed, with the carpal-tunnel-syndrome glove, the golfer’s outfits, the hair. “Kristen Wiig told us that Melissa was the funniest person she knew, but I was not familiar with her,” admits Judd Apatow, who produced Bridesmaids. “I’d get to the set a half-hour early every morning,” she says, “and then just sit in my car, saying, ‘Dial it down, maybe people need a little not-Melissa time.'” McCarthy made Megan seem both real and hilariously outsize, and the joy she took in every aspect of her performance – the unflattering clothes, the utilitarian ponytail, Megan giving off a lesbian vibe but being voraciously hetero – lit up the screen like a 500-watt bulb. Megan was McCarthy’s breakout role: a performance funnier, filthier and more gloriously over-the-top than anything she’d done on Gilmore Girls (where she played Lauren Graham’s best friend for seven years), or Mike & Molly, the fairly conventional sitcom she co-stars in on CBS. He makes me gut-laugh all day, every day of my life.” The funniest person alive: “It’s my husband. Maybe that’s why it stands out: They can say, ‘I’m doing OK! I haven’t shit in the sink this year.'” She grins. “That embarrassment-horror mix is visceral, and people are so glad it’s not them.
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“You’re covering your eyes and trying to make it stop,” she says. McCarthy thinks the bathroom scene plays out like a horror movie. Melissa McCarthy as Megan, the groom’s sister in Bridesmaids: a take-no-prisoners alpha gal who bites Kristen Wiig on the ass, attempts to seduce an air marshal on a flight to Vegas, and, most memorably, copes with a gastrointestinal emergency at a hoity-toity bridal shop by hiking up her dress, planting herself on a bathroom sink and shouting, “Look away!” Melissa McCarthy in real life: sweet and gracious, with a voice just a few decibels above a whisper. This story is from the Septemissue of Rolling Stone.